Publications

(*equal contributions; #corresponding authors)

"Molecular mechanism of Rubisco activase: dynamic assembly and Rubisco remodeling." Waheeda, K., Kitchel, H., Wang, Q., and Chiu, P.-L. Frontiers in Molecular Biosciences (2023). (in press) 

"Molecular asymmetry of photosynthetic supercomplex from green sulfur bacteria." Puskar, R., Truong, C.D., Swain, K., Chowdhury, S., Chan, K.-Y., Li, S., Cheng, K.-W., Wang, T.Y., Poh, Y.-P., Mazor, Y., Liu, H., Chou, T.-F., Nannenga, B.L., and Chiu, P.-L. Nature Communications, 13, 5824 (2022). 

"Coarse-grained simulations for the characterization and optimization of hybrid protein-DNA nanostructures." *Narayanan, R.P., *Procyk, J., Nandi, P., Prasad, A., Xu, Y., Poppleton, E., Williams, D.R., Zhang, F., Yan, H., #Chiu, P.-L., #Stephanopoulos, N., and #Šulc, P. ACS Nano, 16, 14086-14096 (2022). 

"Probing structural perturbation of biomolecules by extracting cryo-EM data heterogeneity." DeVore, K. and Chiu, P.-L. Biomolecules, 12, 628 (2022). 

"ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome." Baker, A.T., Boyd, R.J., Sarkar, D., Crespo, A.T., Chan, C.K., Bates, E., Waraich, K., Vant, J., Wilson, E., Truong, C.D., Lipka-Lloyd, M., Fromme, P., Vermaas, J., Williams, D., Machiesky, K., Heurich, M., Nagalo, B.M., Coughlan, L., Umlauf, S., Chiu, P.-L., Rizkallah, P.J., Cohen, T.S., Parker, A.L., Singharoy, A., and Borad, M.J. Science Advance, 7, eabl8213 (2021). 

"Sample preparation using lipid monolayer method for electron crystallographic studies." Truong, C.D., Williams, D., Zhu, M., Wang, J.C.-H., and Chiu, P.-L. Journal of Visualized Experiments, 177, e63015 (2021). 

"Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity." *Zhang, X., *Gui, L., *Li, S., *Nandi, P., Wong, D.E., Moen, D.R., Lin, H.J., #Chiu, P.-L., and #Chou, T.-F. Biochemical Journal, 478, 3185-3204 (2021). 

"Structural and functional analysis of disease-linked p97 mutant complexes." Nandi, P., Li, S., Columbres, R.C.A., Wang, F., Williams, D.R., Poh, Y.-P., #Chou, T.-F., and #Chiu, P.-L. International Journal of Molecular Sciences, 22, 8079 (2021). 

"Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta." Truong, C.D., Craig, T.A., Cui, G., Botuyan, M.V., Serkasevich, R.A., Chan, K.-Y., #Mer, G., #Chiu, P.-L., and #Kumar, R. Journal of Biological Chemistry, 297, 100912 (2021). 

"Protein secondary structure signatures from energy loss spectra recorded in the electron microscope." March, K., Venkatraman, K., Truong, C.D., Williams, D., Chiu, P.-L., and Rez, P. Journal of Microscopy, 282, 215-223 (2021). 

"Sample preparation and data collection for electron crystallographic studies on membrane protein structures and lipid-protein interaction." Chan, K.-Y., Truong, C.D., Poh, Y.-P., and Chiu, P.-L. Methods in Molecular Biology, 2215, 247-265 (2021). 

"Structural basis of redox modulation on chloroplast ATP synthase." Yang, J.-Y., Williams, D., Kandiah, E., #Fromme, P., and #Chiu, P.-L. Communications Biology, 3, 482 (2020). 

"A library of aminoglycoside-derived lipopolymer nanoparticles for delivery of small molecules and nucleic acids." Godeshala, S., Miryala, B., Dutta, S., Christensen, M.D., Nandi, P., Chiu, P.-L., and Rege, K. Journal of Materials Chemistry B, 8, 8558-8572 (2020). 

"Dynamic self-assembly of detonation nanodiamond in water." Chang, S.L.Y., Reineck, P., Williams, D., Bryant, G., Opletal, G., El-Demrdash, S.A., Chiu, P.-L., Ōsawa, E., Barnard, A.S., and Dwyer, C. Nanoscale, 12, 5363-5367 (2020). 

"Membrane directed expression in Escherichia coli of BBA57 and other virulence factors from the Lyme disease agent Borrelia burgdorfeni." Robertson, K.E., Truong, C.D., Craciunescu, F.M., Yang, J.-Y., Chiu, P.-L., Fromme, P., and Hansen, D.T. Scientific Reports, 9, 1-15 (2019). 

"The C. elegans 3'UTRome V2: an updated genomic resource to study 3'UTR biology. " Steber, H.S., Gallante, C., Chiu, P.-L., and Mangone, M. Genome Research, 29, 2104-2116 (2019). 

Toporik, H., Li, J., Williams, D., Chiu, P.-L., and Mazor, Y. (2019). "The structure of the photosystem I IsiA super-complex." Nature Structural and Molecular Biology, 26, 443-449. 

*Aryal, R.P., *Kwak, P.B., *Tamayo, A.G., Chiu, P.-L., Walz, T., and Weitz, C.J. (2017). "Macromolecular assemblies of the mammalian circadian clock." Molecular Cell, 67, 770-782. 

*Kalbermatter, D., *Chiu, P.-L., Jeckelmann, J.-M., Ucurum, Z., Walz, T., and Fotiadis, D. (2017). "Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change." Journal of Structural Biology, 199, 39-45. 

Leksa, N.C., Chiu, P.-L., Bou-Assaf, G.M., Quan, C., Liu, Z., Goodman, A.B., Chambers, M.G., Tsutakawa, S.E., Hammal, M., Peters, R.T., Walz, T., and Kulman, J.D. (2017). "The structural basis for the functional comparability of factor VIII and the long-acting variant rFVIIIFc." Journal of Thrombosis and Haemostasis, 15, 1167-1179. 

Klara, S.S., Saboe, P.O., Sines, I.T., Babaei, M., Chiu, P.-L., DeZorzi, R., Dayal, K., Walz, T., Kumar, M., and Mauter, M.S. (2016). "Magnetically directed two-dimensional crystallization of OmpF membrane proteins in block copolymers." Journal of the American Chemical Society, 138, 28-31. 

*Chiu, P.-L., *Li, X., Li, Z., Beckett, B., Brilot, A.F., Grigorieff, N., Agard, D.A., Cheng, Y., and Walz, T. (2015). "Evaluation of super-resolution performance of the K2 electron counting camera using 2D crystals of aquaporin-0." Journal of Structural Biology, 192, 163-173. 

Kalbermatter, D., Jeckelmann, J.-M., Chiu, P.-L., Ucurum, Z., Walz, T., and Fotiadis, D. (2015). "2D and 3D crystallization of the wild-type IIC domain of the glucose PTS transporter from Escherichia coli." Journal of Structural Biology, 191, 376-380. 

*Chiu, P.-L., *Bou-Assaf, G., Chhabra, E.S., Chambers, M.G., Liu, L., Peters, R., Kulman, J.D., and Walz, T. (2015). "Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry." Blood, 126, 935-938. 

Commentary in Blood: Krishnaswamy, S. (2015). "FVIII-VWF dos-à-dos." Blood, 126, 923-924.

*Hite, R.K., *Chiu, P.-L., Schuller, J., and Walz, T. (2015). "Effect of lipid head groups on double-layered two-dimensional crystals fromed by aquaporin-0." PLoS ONE, 10, e0117371.

Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P.-L., Rangl, M., Scheuring, S., Nimigean, C.M., and Stahlberg, H. (2014). "Ligand-induced structural changes in the cyclic nucleotide-modulateed potassium channel MloK1." Nature Communications, 5, 3106-3115. 

Hopkins, L.E., Patchin, E.S., Chiu, P.-L., Brandenberger, C., Smiley-Jewell, S., and Pinkerton, K.E. (2014). "Nose-to-brain transport of aerosolized quantum dots following acute exposure." Nanotoxicology, 8, 885-893. 

Evans, J.E., Jungjohann, K.L., Wong, P.C.K., Chiu, P.-L., Dutrow, G.H., Arslan, I., and Browning, N.D. (2013). "Visualizing macromolecular complexes with in situ liquid scanning transmission electron microscopy." Micron, 43, 1085-1090. 

Chiu, P.-L., Kelly, D.F., and Walz, T. (2011). "The use of trehalose in the preparation of specimens for electron microscopy." Micron, 42, 762-772. 

Paoli, E.-E., Kruse, D.E., Seo, J.W., Zhang, H., Kheirolomoom, A., Watson, K.D., Chiu, P.-L., Stahlberg, H., and Ferrara, K.W. (2010). "An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: importance of formulation." Journal of Control Release, 143, 13-22. 

Chiu, P.-L., Pagel, M.D., Evans, J.E., Chou, H.-T., Zeng, X., Gipson, B., Stahlberg, H., and Nimigean, C.M. (2007). "The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 Å resolution." Structure, 15, 1053-1064. 

Feature in Structure: Taraska, J.W. and Zagotta, W. (2007). "Cyclic nucleotide-regulated ion channel: Spotlight on symmetry." Structure, 15, 1023-1024.

Renault, L., Chou, H.-T., Chiu, P.-L., Hill, R.M., Zeng, X., Gipson, B., Zhang, Z.Y., Cheng, A., Unger, V., and Stahlberg, H. (2006). "Milestones in electron crystallography." Journal of Computational Aided Molecular Design, 20, 519-527. 

Chiu, P.-L., Wu, C.-Y., Taso, J.-H., and Chang, F.-H. (2001). "Drug delivery through liposome by ultrasonic cavitation." Biomedical Engineering-Application, Basis, & Communications, 13, 47-52.